Selected Publications and Abstracts

Publications

Modulation of mitochondrial function by the microbiome metabolite propionic acid in autism and control cell lines. Frye RE, Rose S, Chacko J, Wynne R, Bennuri SC, Slattery JC, Tippett M, Delhey L, Melnyk S, Kahler SG, MacFabe DF. Transl Psychiatry. 2016 Oct 25;6(10):e927. doi: 10.1038/tp.2016.189.

The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Slattery J, MacFabe DF, Frye RE. Clin Med Insights Pediatr. 2016 Oct 9;10:91-107. Review.

Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? Slattery J, MacFabe DF, Kahler SG, Frye RE. Curr Pharm Des. 2016 Sep 5.

MACFABE, Derrick F.. Enteric short-chain fatty acids: microbial messengers of metabolism, mitochondria, and mind: implications in autism spectrum disorders.Microbial Ecology in Health and Disease, [S.l.], v. 26, may. 2015. ISSN 1651-2235.

Richard E. Frye, John Slattery, Derrick F. MacFabe, Emma Allen-Vercoe, William Parker, John Rodakis, James B. Adams, Rosa Krajmalnik-Brown, Ellen Bolte, Stephen Kahler, Jana Jennings, Jill James, Carl E. Cerniglia, Tore Midtvedt, Approaches to studying and manipulating the enteric microbiome to improve autism symptoms (Published: 7 May 2015)

Richard E. Frye, Shannon Rose, John Slattery, Derrick F. MacFabe, Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome (Published: 7 May 2015)

John Slattery, Derrick F. MacFabe and Richard E. Frye. The Significance of the Enteric Microbiome on the Development of Childhood Disease: A Review of Prebiotic and Probiotic Therapies in Disorders of Childhood. Clini al Medi ine nsights: Pediatri s 2016:10

RE Frye, S Rose, J Chacko, R Wynne, SC Bennuri, JC Slattery, M Tippett, L Delhey, S Melnyk, SG Kahler and DF MacFabe. Modulation of mitochondrial function by the microbiome
metabolite propionic acid in autism and control cell lines.
Citation: Transl Psychiatry (2016) 6, e927; doi:10.1038/tp.2016.189

John Slattery, Derrick F. MacFabe, Stephen G. Kahler and Richard E. Frye. Enteric Ecosystem Disruption in Autism Spectrum Disorder: Can the Microbiota and Macrobiota be Restored? Current Pharmaceutical Design, 2016, 22, 1-15

Nankova BB, Agarwal R, MacFabe DF, La Gamma EF. Enteric Bacterial Metabolites Propionic and Butyric Acid Modulate Gene Expression, Including CREB-Dependent Catecholaminergic Neurotransmission, in PC12 Cells - Possible Relevance to Autism Spectrum Disorders. 2014 Aug 29;9(8):e103740. doi: 0.1371/journal.pone.0103740. eCollection 2014.

Foley KA, Macfabe DF, Vaz A, Ossenkopp KP, Kavaliers M. Sexually dimorphic effects of prenatal exposure to propionic acid and lipopolysaccharide on social behavior in neonatal, adolescent, and adult rats: Implications for autism spectrum disorders. Int J Dev Neurosci. 2014 Apr 18. pii: S0736-5748(14)00055-0. doi: 10.1016/j.ijdevneu.2014.04.001

Foley KA, Ossenkopp K-P, Kavaliers M, MacFabe DF (2014) Pre- and Neonatal Exposure to Lipopolysaccharide or the Enteric Metabolite, Propionic Acid, Alters Development and Behavior in Adolescent Rats in a Sexually Dimorphic Manner. PLoS ONE 9(1): e87072. doi:10.1371/journal.pone.0087072

MacFabe, D.F. Autism: Metabolism, Mitochondria, and the Microbiome Global Adv Health Med. 2013;2(6):52-66. DOI:10.7453/gahmj.2013.089

Frye RE, Rossignol D, Casanova MF, Brown GL, Martin V, Edelson S, Coben R, Lewine J, Slattery JC, Lau C, Hardy P, Fatemi SH, Folsom TD, MacFabe D and Adams JB (2013) A review of traditional and novel treatments for seizures in autism spectrum disorder: findings from a systematic review and expert panel. Front. Public Health 1:31. doi: 10.3389/fpubh.2013.00031

Frye RE, Melnyk S, MacFabe DF. Unique acyl-carnitine profiles are potential biomarkers for acquired mitochondrial disease in autism spectrum disorder. Translational Psychiatry 2013, 3: e220. doi: 10.1038/tp.2012.143

MacFabe, D.F. Short-chain fatty acid fermentation products of the gut microbiome: implications in autism spectrum disorders. Microbial Ecology in Health & Disease 2012, 23: 19260

Thomas, R.H, Meeking, M. M., Mepham, J.R., Tichenoff, L.J., Possmayer, F. Suya Liu and MacFabe, D.F. The enteric bacterial metabolite propionic acid alters brain and plasma phospholipid molecular species: further development of a rodent model of autism spectrum disorders. J. of Neuroinflammation –accepted May 2012

Shultz, S.R., MacFabe, D.F., Foley, K.A., Taylor, A.R., Cain, D.P . Sub concussive brain injury in the Long-Evans rat induces acute neuroinflammation in the absence of behavioral changes: Support for an animal model of concussion. behavioral Brain Research – 2011 Dec 19;229(1):145-152.

Ossenkopp, K-P., Foley, K.A., Gibson, J., Fudge, M.A., Kavaliers, M., Cain, D.P., MacFabe, D.F Systemic treatment with the enteric bacterial fermentation product, propionic acid, produces both conditioned taste avoidance and conditioned place avoidance in rats. behavioral Brain Research – 2011 Nov 9; (1):134-141

Shultz, S.R., MacFabe, D.F., Foley, K.A., Taylor, A.R., Cain, D.P. A single mild fluid percussion injury induces short-term behavioral and neuropathological changes in the Long-Evans rat: Support for an animal model of concussion. behavioral Brain Research – Volume 224 (2011) 326-335.

Nie H.-Y., Taylor A.R., Lau W.M., MacFabe, D.F. Subcellular features revealed on unfixed rat brain sections by phase imaging. Analyst, 2011, 136, 2270.

Derrick F. MacFabe, Nathan E.Cain, Francis Boon, Klaus-PeterOssenkopp, Donald P.Cain. Effects of the enteric bacterial metabolic product propionicacid on object-directed behavior,social behavior,cognition,and neuroinflammation in adolescent rats:Relevance to autism spectrum disorder. behavioral Brain Research 217(2010)47–54.

R.H. Thomas, K. A. Foley, J. R. Mepham, L.J. Tichenoff, F. Possmayer and D.F. MacFabe. Altered brain phospholipids and acylcarnitines in a propionic acid induced rodent model for autism spectrum disorder. Journal of Neurochemistry 113:515-529 April 2010.

H.-Y. Nie, A.R. Taylor, J. T. Francis, M. J. Walzak, W. M. Lau and D. F. MacFabe, Tracing propionic acid infused to rat brain via deuterium tagging – further development of a novel rodent model of autism spectrum disorders, Surface and Interface Analysis March 2010.

Sandy R. Shultz, Derrick F. MacFabe, Samantha Martin, Jordana Jackson, Roy Taylor, Francis Boon, Klaus-Peter Ossenkopp, Donald P. Cain, Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long–Evans rat: Further development of a rodent model of autism (2009 in Press)

Derrick F. MacFabe et al., Neurobiological effects of intraventricular propionic acid in rats: Possible role of short chain fatty acids on the pathogenesis and characteristics of autism spectrum disorders, behavioral Brain Research (2006), doi:10.1016/j.bbr.2006.07.025

Derrick F. MacFabe, Karina Rodríguez-Capote, Jennifer E. Hoffman, Andrew E. Franklin, Yalda Mohammad-Asef, A. Roy Taylor, Francis Boon, Donald P. Cain, Martin Kavaliers, Fred Possmayer and Klaus-Peter Ossenkopp, A Novel Rodent Model of Autism: Intraventricular Infusions of Propionic Acid Increase Locomotor Activity and Induce Neuroinflammation and Oxidative Stress in Discrete Regions of Adult Rat Brain, American Journal of Biochemistry and Biotechnology 4 (2): 146-166, 2008.

Sandy R. Shultz, Derrick F. MacFabe, Klaus-Peter Ossenkopp, Shannon Scratch, Jennifer Whelan, Roy Taylor, Donald P. Cain, Intracerebroventricular injection of propionic acid, an enteric bacteria lmetabolic end-product, impairs social behavior in the rat: Implications for an animal model of autism, Neuropharmacology 54: 901-911, 2008.

H.-Y. Nie, J.T. Francis, A.R. Taylor, M.J. Walzak, W.H. Chang, D.F. MacFabe and W.M. Lau, "Imaging subcellular features of a sectioned rat brain using time-of-flight secondary ion mass spectrometry and scanning probe microscopy",DOI: 10.1016/j.apsusc.2008.05.149

J.T. Francis, H.-Y. Nie, A.R. Taylor, M.J. Walzak, W.H. Chang, D.F. MacFabe and W.M. Lau, "ToF-SIMS cluster ion imaging of hippocampal CA1 pyramidal rat neurons", DOI:10.1016/j.apsusc.2008.05.258

Derrick F. MacFabe, Autism and the Digestive System, Exceptional Parent Magazine, November 2007

Derrick F. MacFabe, The Epidemic of Autism: Growing Neurobiological Links to Genetics, Environment and behavior. Aspire Magazine Special Autism Issue, Fall 2007

Abstracts

Foley KA; MacFabe DF; Kavaliers M; Ossenkopp K-P. Prenatal exposure to propionic acid produces developmental delay, hypersensitivity to acoustic startle, and social impairment in adolescent rats. International Behavioral Neuroscience Society, Hawaii, USA, 2012.

R. H. Thomas, J.R. Mepham, L. Tichenoff, F. Boon, F. Possmayer, D.F. MacFabe The enteric bacterial metabolite propionic acid alters brain and plasma intact phospholipid molecular species: Implications in Autism spectrum Disorders. International Meeting for Autism Research (IMFAR), Toronto Ontario, May 2012.

D. F. MacFabe, R. Agarwal, L. J. Tichenoff, A. R. Taylor, E. LaGamma, B. B. Nankova Intraventricular Enteric Short Chain Fatty Acid Infusions in Rats Induce behavioral, Neuropathological, Lipid and Epigenetic Changes Consistent with Autism. International Meeting for Autism Research (IMFAR), Toronto Ontario, May 2012.

D. F. MacFabe, R. Frye Acyl-carnitine abnormalities in autistic children parallel abnormalities in a rodent model of autism. International Meeting for Autism Research (IMFAR), Toronto Ontario, May 2012.

Holbrook, S., Boon, F., Taylor, R., Thomas R., Tichenoff, L., Kavaliers, M., Ossenkopp, K.P, MacFabe, D.F. The temporal relationship of behavioral, neuropathological and lipid fluctuations following a single intraventricular infusion of Propionic Acid in rats. International Meeting for Autism Research (IMFAR), Toronto Ontario, May 2012.

Foley KA, Kavaliers M, Ossenkopp K-P, MacFabe DF Prenatal exposure to propionic acid and lipopolysaccharide produces developmental delay, anxiety-like behavior, and hyper-sensitivity to acoustic startle in adolescent rats. International Meeting for Autism Research (IMFAR), Toronto Ontario, May 2012.

MacFabe, D.F., Thomas, R., Tichenoff, L.J., Ossenkopp, K.P. American Society for Neurochemistry 2012 conference. Baltimore, Maryland, 2012

MacFabe, D.F., Foley, K.A., Boon, F., Tichenoff, L.J., Ossenkopp, K.P.American Society for Neurochemistry 2012 conference. Baltimore, Maryland, 2012

MacFabe, D.F., Ossenkopp, K.P., Kavaliers, M., Foley, K.A.Prenatal administration of propionic acid, produces developmental delay and behavioral in adolescent rats. American Society for Neurochemistry 2012 conference. Baltimore, Maryland, 2012

Foley KA, Kavaliers M, Ossenkopp K-P, MacFabe DF Prenatal exposure to propionic acid and lipopolysaccharide produces developmental delay and hyper-sensitivity to acoustic startle in adolescent rats. Society for Neuroscience Annual Meeting, Washington, DC. November 2011.

Holbrook, S., Boon, F., Taylor, R., Thomas R., Tichenoff, L., Ossenkopp, K.P, MacFabe, D.F. Temporal effects of single intracerebroventricular infusions of Propionic Acid on behavioral, Neuropathological and Lipid changes in rats: Further development of a novel rodent model of Autism. Society for Neuroscience Annual Meeting, Washington, DC. November 2011.

J. R. Mepham, F. Boon, A.R. Taylor, R.H. Thomas, D.P Cain, K.-P. Ossenkopp, & D.F. MacFabe Time course of propionic acid induced lipid neuroinflammatory and cognitive deficits in the Morris water maze-further development of a novel rodent model of autism. Society for Neuroscience Annual Meeting, Washington, DC. November 2011.

R. H. Thomas, J.R. Mepham, L. Tichenoff, F. Boon, F. Possmayer, D.F. MacFabe Intracerebral and oral administration of propionic acid (an enteric bacterial metabolite) alters brain carnitine and acylcarnitines in rodents consistent with autism spectrum disorders. Society for Neuroscience Annual Meeting, Washington, DC. November 2011.

D.F. MacFabe, D.P. Cain, A.R. Taylor, K.A. Foley, F. Boon, F. Possmayer, M. Kavaliers, K.P. Ossenkopp. Central (ICV) administration of propionic acid as a rodent model of ASD: Neuropathological validity. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

R. H. Thomas, M.M. Meeking, J.R. Mepham, L.J. Tichenoff, F.Possmayer and D. F. MacFabe. Alterations in plasma and brain lipid profiles: Further development of the propionic acid induced rodent model of autism spectrum disorder. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

D.F. MacFabe, N.E. Cain, F.H. Boon, K.-P. Ossenkopp, A.R. Taylor, D.P.Cain. Effects of the enteric bacterial metabolic product propionic acid on repetitive behaviors, social behaviors, cognition, and neuroinflammation in juvenile and adult rats: Contributions to a rodent model of autism spectrum disorders. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

K.-P. Ossenkopp, D.P. Cain, F. Boon, L. Tichenoff, M. Kavaliers, K.A. Foley, D.F. MacFabe. Central (ICV) administration of propionic acid as a rodent model of ASD: behavioral validity. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

J. Benzaquen, K.A. Foley, L. Tichenoff, D.F. MacFabe, M. Kavaliers, K.-P. Ossenkopp. The effects of intraperitoneal injections of propionic acid on juvenile male and female rat locomotor and social behavior: Further development of an animal model of autism. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

J. Mepham, F. Boon, D.P. Cain, K.-P. Ossenkopp, D.F. MacFabe. Investigating the permanence of propionic acid-induced cognitive deficits in the Morris water maze. Society for Neuroscience Annual Meeting, San Diego, California. November 2010.

Shultz, S.R., MacFabe, D.F., Foley, K., Taylor, R., Cain, D.P. (2010). An animal model of sports-related concussion and chronic traumatic encephalopathy: The effects of repeated mild fluid percussion injury on behavior and neuropathology in the rat International Brain Injury Association Meeting Planner, Eighth World Congress on Brain Injury, Washington, DC, March 10-14, 2010.

R.H. Thomas, K. A. Foley, J. R. Mepham, L.J. Tichenoff, and D.F. MacFabe. Altered brain phospholipids and acylcarnitines in a propionic acid induced rodent model for autism spectrum disorder. International Meeting for Autism Research (IMFAR), Philadelphia, Pennsylvania. April 2010.

D.F. MacFabe, R. Agarwal, L.J. Tichenoff, A.R. Taylor, E. LaGamma, and B.B. Nankova. Intraventricular infusions of enteric short chain fatty acids induce behavioral, neuropathological and epigenetic changes in rats: Further development of a novel rodent model of autism. International Meeting for Autism Research (IMFAR), Philadelphia, Pennsylvania. April 2010.

K. A. Foley, L.J. Tichenoff, K.-P. Ossenkopp, and D.F. MacFabe. Neonatal administration of propionic acid alters startle response magnitude in adolescent rats. International Meeting for Autism Research (IMFAR), Philadelphia, Pennsylvania. April 2010.

S.R. Shultz, D.F. MacFabe, D.P. Cain. The effects of repeated mild fluid percussion injury on cognition, anxiety, depression, social behavior and sensorimotor function in the rat: An animal model of sports-related concussion. Society for Neuroscience Annual Meeting, Chicago, Illinois. October 2009.

M.M. Meeking, K.A. Foley, L.J. Tichenoff, K.P. Ossenkopp, D.F. MacFabe. Assessing exploratory and repetitive behavior in Long-Evans rats in a propionic acid model of autism spectrum disorder. Society for Neuroscience Annual Meeting, Chicago, Illinois. October 2009.

K.A. Foley, L.J. Tichenoff, K.P. Ossenkopp, D.F. MacFabe. Neonatal administration of propionic acid alters startle response magnitude and pre-pulse inhibition in adolescent rats. Society for Neuroscience Annual Meeting, Chicago, Illinois. October 2009.

R.H. Thomas, F. Possmayer, H.-Y. Nie, K. Foley, L.Tichenoff, D.F. MacFabe. The effects of short chain fatty acids on the brain fatty acid composition in the propionic acid rodent model of autism. Society for Neuroscience Annual Meeting, Chicago, Illinois. October 2009.

S.Shams, M. Kavaliers, K.A.Koley, K.-P. Ossenkopp, D.F. MacFabe. Reduced social interaction, anxiety-like behavior and hypoactivity following systemic administrations of propionic acid in juvenile male rats. Society for Neuroscience Annual Meeting, Chicago, Illinois. October 2009.

Nie, H.-Y., Francis, J.T., Walzak, M.J., Lau, W.M, Taylor, A.R., MacFabe, D.F. Tracing propionic acid infused to rat brain via deuterium tagging. SIMS Conference, Toronto, Ontario September 2009.

Yama B, Zou G.Y., Freeman T, MacFabe D.F., Campbell M.K. Screening for Autism in a Prenatally Assembled Cohort. Canadian Society for Epidemiology and Biostatistics / Association of Public Health Epidemiologists in Ontario Conference, May 2009

Mohammad-Asef Y, Nankova, B.B., Tichenoff, L., Taylor, A.R., La Gamma, E. F., MacFabe, D.F. Intraventricular infusions of the enteric bacterial metabolites propionic and butyric acid induce behavioral, neuropathological and epigenetic changes in rats: a novel model of autism spectrum disorders. Society for Neuroscience Annual Meeting, Washington D.C., November 2008.

MacFabe, D.F., Nie, H.-Y., Francis, J.T., Taylor, A.R., Tichenoff, L., Walzak, M.J., Chang, W.H., Ossenkopp, K-P, Lau, W.M. Time-of-flight secondary ion mass spectroscopy (Tof-SIMS) of brain tissue reveals evidence of white matter edema, increased oxidative stress and altered lipid profiles in a novel propionic acid rodent model of autism. Society for Neuroscience Annual Meeting, Washington D.C., November 2008.

Foley, K.A., Tichenoff, L., Fortinsky, K., Taylor, A.R., Boon, F., Ossenkopp, K.-P., MacFabe D.F. Intraventricular infusions of propionic acid increases locomotor activity and neuroinflammation in juvenile rats: an animal model of autism spectrum disorders. Society for Neuroscience Annual Meeting, Washington D.C., November 2008.

Shams, S., Kavaliers, M., Foley, K.A., MacFabe, D.F., Ossenkopp, K.-P. Effects of systemic administration of propionic acid on social interaction in juvenile rats: A rodent model of autism. Society for Neuroscience Annual Meeting, Washington D.C., November 2008.

Gordon, M.M., Foley, K.A., Taylor, A.R., Boon, F., Tichenoff, L., Ossenkopp, K.-P., MacFabe D.F. Repeated intraventricular administration of propionic acid produces increased locomotor activity and neuroinflammation in rats: A novel rodent model of autism spectrum disorders. Canadian Society for Brain, behavior and Cognitive Science 18th Annual Meeting, London, ON, June 2008.

Shams, S., Kavaliers, M., Foley, K.A., MacFabe, D.F., Ossenkopp, K.-P. Effects of intraperitoneal administration of propionic acid on social interaction in juvenile rats: A model for autism. Canadian Society for Brain, behavior and Cognitive Science 18th Annual Meeting, London, ON, June 2008.

Martins, J., Foley, K. A., Hoffman, J. E., Taylor, R., Boon, F., Tichenoff, L., Mohammad Asef, Y., Cain, D. P., Kavaliers, M., Ossenkopp, K. P., & MacFabe, D. F. Effects of NMDA and dopamine receptor antagonists on locomotor hyperactivity in a novel propionic acid rodent model of autism. Canadian Association for Neuroscience, Montreal, Ontario, May 2008.

Foley K.A., Gordon M.M., Taylor A.R., Boon F., Tichenoff L.J., Ossenkopp K.P., MacFabe D.F. Increased locomotor activity, neuroinflammation, and monocarboxylate transporter immunoreactivity following intraventricular infusions of propionic acid in rats: spaced vs chronic administration. Canadian Association for Neuroscience, Montreal, Ontario, May 2008.

Nankova, B.B., Tichenoff, L., Taylor, A.R., Mohammad-Asef Y., La Gamma, E. F., MacFabe, D.F. Intraventricular infusions of the enteric short chain fatty acids, propionic and butyric acid, induce behavioral, neuropathological and epigenetic changes in rats: Possible relevance to autism spectrum disorders. Canadian Association for Neuroscience, Montreal, Ontario, May 2008.

MacFabe, D.F., Nie, H.-Y., Francis, J.T., Taylor, A.R., Tichenoff, L., Ossenkopp, K-P. , Walzak, M.J., Chang, W.H., Lau, W.M. Use of Time-of-Flight Secondary Ion Mass Spectroscopy (Tof-SIMS) to analyze white matter edema, increased oxidative stress, and altered lipid profiles in propionic acid treated rat brain: implications for Autism Spectrum Disorders. Canadian Association for Neuroscience, Montreal, Ontario, May 2008.

Martins, J., Foley, K.A., Hoffman, J.E., Taylor, A.R., Boon, F., Tichenoff, L.J., Mohammad-Asef, Y., Cain, D.P., Kavaliers, M., Ossenkopp, K.P., MacFabe, D.F. Role of NMDA and dopamine receptor antagonists in a novel propionic acid rodent model of autism. International Meeting for Autism Research (IMFAR) London, England - May 2008.

Foley, K.A., Gordon M.M., Taylor, A.J., Boon, F., Tichenoff, L.J., Ossenkopp, K.P., MacFabe, D.F. Intraventricular infusions of propionic acid increases locomotor activity, neuroinflammation, and monocarboxylate transporter immunoreactivity in rats: spaced vs. chronic administration. International Meeting for Autism Research (IMFAR) London, England - May 2008.

Nankova, B.B., Tichenoff, L.J., Taylor, A.R., Mohammad-Asef Y., La Gamma, E.F., MacFabe, D.F. Intraventricular infusions of propionic and butyric acid induce behavioral, nueropathological and epigenetic changes in rats : possible relevance to autism spectrum disorders. International Meeting for Autism Research (IMFAR) London, England - May 2008.

MacFabe, D.F., Nie, H.-Y., Francis, J.T., Taylor, A.R., Tichenoff, L., Walzak, M.J., Chang, W.H., Lau, W.M. Time-of-Flight Secondary Ion Mass Spectroscopy (ToF-SIMS) of brain tissue in a novel propionic acid rodent model of autism – evidence of white matter edema, increased oxidative stress and altered lipid profiles. International Meeting for Autism Research (IMFAR) London, England - May 2008.

Gordon, M.M., Foley, K.A., Boon, F., Tichenoff, L., Ossenkopp, K.-P., MacFabe, D.F. Effect of daily infusions of propionic acid on locomotor activity in an adult rodent model of autism spectrum disorders. Southern Ontario Neuroscience Association Annual Meeting, London, ON, May 2008.

Shams, S., Kavaliers, M., MacFabe, D.F., Ossenkopp, K.-P. Effects of intraperitoneal administration of propionic acid on social interaction in juveniles: A model for autism. Southern Ontario Neuroscience Association Annual Meeting, London, ON, May 2008.

MacFabe, D.F.,Mohammad-Asef, Y., Taylor, R., Hoffman, J.E., Tichenoff, L., Cain, D. P., Boon, F., Ossenkopp, K.P. Spaced intraventricular injections of propionic acid in rats produces reversible social impairments and elicits more extensive neuroinflammatory effects than chronic infusions: implications for autism spectrum disorders. Society for Neuroscience Annual Meeting, San Diego, California, November 2007.

Bistra B. Nankova, D. F. MacFabe and Edmund F. La Gamma. Short chain fatty acids induce catecholaminergic neurotransmission in PC12 cells via a CREB dependant mechanism - possible relevance to autism spectrum disorders. Society for Neuroscience Annual Meeting, San Diego, California, November 2007.

Shultz, S., MacFabe, D.F., Scratch, S., Jackson, J., Martin, S., Boon, F., Ossenkopp, K.P., Cain, D.P Intraventricular injections of propionic acid induce social, cognitive and sensorimotor impairments in long evans rats. Society for Neuroscience Annual Meeting, San Diego, California, November 2007.

K.P. Ossenkopp, K.A. Foley, R. Taylor, D.P. Cain, M. Kavaliers, D.F. MacFabe. Startle response magnitude and prepulse inhibition in a propionic acid rodent model of autism spectrum disorder. Society for Neuroscience Annual Meeting, San Diego, California, November 2007.

Shultz, S., MacFabe, D.F, Scratch, S., Jackson, J., Whelan, J., Martin, S., Boon, F., Taylor, R., Ossenkopp, K.P., Cain, D.P. Intraventricular infusions of propionic acid reversibly impair social behavior and induce neuroinflammatory changes long evans rats. Canadian Association for Neuroscience, Toronto, Ontario, 2007.

Hoffman, J.E. , Taylor, R., Mohammad Asef, Y., Boon, F., Cain, D.P., Kavaliers, M. Ossenkopp, K.P., MacFabe, D.F., Propionic acid but not control compounds induce increased locomotor activity and innate neuroinflammatory changes in rats following ventricular infusion- A novel animal model for autism spectrum disorders. Canadian Association for Neuroscience, Toronto, Ontario, 2007.

MacFabe, D.F. Hoffman, J.E., Taylor, R., Mohammad Asef, Y., Cain, D. P., Boon, F., Kavaliers, M., Ossenkopp, K.P. Infusions of propionic acid induces increased locomotor activity, neuroinflammatory effects, fatty acid transport, blood brain barrier and neuroplastic changes in rats following intraventricular infusion-relevance to autism spectrum disorders. Canadian Association for Neuroscience, Toronto, Ontario, 2007.

Nankova, B, MacFabe, D. F. & La Gamma, E. Short chain fatty acids induce catecholaminergic neurotransmission in PC12 cells via a creb dependant mechanism-possible relevance to autism spectrum disorders. Canadian Association for Neuroscience, Toronto, Ontario, 2007.

MacFabe, D.F. Hoffman, J.E., Taylor, R., Cain, D. P., Boon, F., Kavaliers, M., Ossenkopp, K.P. Intraventricular infusions of propionic acid induces increased locomotor activity, neuroinflammatory effects, and fatty acid transport and blood brain barrier changes in rats. International Meeting for Autism Research (IMFAR) Seattle, Washington, Abstracts, 2007.

Hoffman, J.E., Taylor, R., Mohammad Asef, Y., Boon, F., Cain, D.P.,Kavaliers, M. Ossenkopp, K.P., MacFabe, D.F. Intraventricular infusions of propionic acid but not control compounds induces increased locomotor activity and innate neuroinflammatory changes in rats. International Meeting for Autism Research (IMFAR) Seattle, Washington, Abstract, 2007.

Shultz, S., MacFabe, D.F, Scratch, S., Jackson, J., Whelan, J., Martin, S., Boon, F., Taylor, R., Ossenkopp, K.P., Cain, D.P. Intraventicular infusions of propionic acid reversibly impair social behavior and induce neuroinflammatory changes in long evans rats. International Meeting for Autism Research (IMFAR) Seattle, Washington, Abstract, 2007.

Nankova, B., MacFabe, D.F. & La Gamma, E. A hypothesis on a dietary link between autism spectrum disorders and central neurotransmission: short chain fatty acids and catecholaminergic neurotransmission. International Meeting for Autism Research (IMFAR) Seattle, Washington, Abstract, 2007.

MacFabe, D.F., Rodríguez-Capote K, Fan, J., Hoffman J.E., Franklin A.E., Possmayer F., Ossenkopp K-P. Intraventricular administration of propionic acid decreases total glutathione, and increases Oxidative stress in rat brain. Abstract Viewer and Itinerary Planner. Atlanta, GA: Society for Neuroscience, CD-ROM, 2006.

Franklin, A.E., Hoffman, J., Taylor, R., Boon, F., Kavaliers, M. Cain, D.P., Ossenkopp, K.P., MacFabe, D.F. Repeated intraventricular infusions of propionic acid induce hyperactivity, neuroinflammatory and cell signaling neuropathological changes in long evans rats. Abstract Viewer and Itinerary Planner. Atlanta, GA: Society for Neuroscience, CD-ROM, 2006.

MacFabe, D.F., Ossenkopp, K.P., Franklin, A.E., Mohammad-Asef, Y., Kavaliers M., Hampson E., Boon, F., Cain, D.P. (2005). Intraventricular infusions of propionic acid induce both behavioral and electrographic responses in long-evans rats. Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, CD-ROM, 2005.

Hoffman, J.E., Franklin, A.E., Taylor, R., Kavaliers, M., Hampson, E., Cain, D.P., Ossenkopp, K.P. MacFabe, D.F. Intraventricular administration of propionic acid induces increased locomotor activity, astrogliosis and white matter changes in long- evans rats. Abstract Viewer and Itinerary Planner. Washington, DC: Society for Neuroscience, CD-ROM, 2005.

Frantseva, M.V., Adamchik, Y., MacFabe, D.F., Naus, C.G., Perez-Velazquez, J.L. Functional studies of an in vitro trauma injury model: Role of gap junctional communication. 5th International Neurotrauma Symposium, Garmisch-Partenkirchen, Germany, October 2000, Restorative Neurology Neuroscience, 16, (3, 4) 152-53, 2000.

MacFabe, D.F., Giacobbe, J., Bechberger, J.F., Leung, L.S., and Naus, C.C., Enhanced hippocampal damage in connexin-43 deficient heterozygotic mice following kainic acid induced seizures. FASEB, San Diego, 2000.

MacFabe, D.F., Adamchik, Y., Perez-Velasquez, J.L., Carlen, P. and Naus, C.C.G. The role of calmodulin and pH on gap junctional gating in rodent hippocampal organotypic explants as measured by the photorecovery after photobleaching (FRAP) technique. FASEB, San Diego, 2000.

Frantseva, M.V., Adamchik, Y., MacFabe, D.F., Naus, C.C., Perez-Velazquez, J.L. Functional studies of an in vitro trauma injury model: Role of gap junctional communication. GARMIS.

MacFabe, D.F., McLachlan, D.R., Baimbridge, K. and Bergeron, C. Calcium binding proteins are differentially distributed in rat, rabbit and human CNS. Cellular Variations in Ca2+ Signalling Symposium Abstract (1988).

MacFabe, D.F., McLachlan, D.R., Baimbridge, K. and Bergeron, C. Immunocytochemical distribution of calmodulin, calbindin D28K and parvalbumin in rat, rabbit and human CNS: Possible relevance to Neurodegenerative Dis¬ease. FIPP Symposium Abstracts p. 18 (1988).

MacFabe, D.F., Lew, J., Scott, B. and Plioplys, A.V. Interferon induces redistribu¬tion of the 210K dalton neurofilament subunit in cultured dorsal root ganglia cell bodies from normal and trisomy 16 mice. Neuroscience Abstract, 1987.

MacFabe, D.F., Borst, G. and Leung, L.S. Cholinergic modulation of electrical activity in the rat cingulate cortex. Canadian College of Neuropsychopharm, 8th Annual Meeting Abstracts, p. 23 1985.

Leung, L.S., Borst, J.G., and MacFabe, D.F. Electrical activity of the cingulate cortex in the rat: Relation to behavior and cholinergic inputs. Neuroscience Abstract, 154 15, 1985.

Stewart, D.J., MacFabe, D.F., and Vanderwolf, C.H. Cholinergic activation of neocortex and hippocampus: Role of substantia innomminata and medial septal diagonal band region. Neuroscience Abstract, 10, 1984.